Which of the following are signs of an overdose?

Breathing problems and severe unresponsiveness are critical indicators of an overdose, particularly in situations involving substances that depress the central nervous system, such as opioids or sedatives. These signs signal extreme impairment in the body's ability to function, which can lead to life-threatening consequences if not addressed immediately. When an individual is severely unresponsive, they may not be able to wake up or respond to stimuli, suggesting that their respiratory function is compromised, which is a direct consequence of an overdose.

The presence of breathing problems also indicates that the lungs are not adequately functioning, often resulting in reduced oxygen flow to vital organs. This combination of symptoms is a clear medical emergency and necessitates immediate intervention to prevent serious harm or death. Monitoring for these signs is crucial in medication administration settings, as they highlight the need for urgent medical evaluation and potential resuscitation efforts.

Other symptoms of overdose, such as rapid heartbeat, excessive sweating, or nausea and vomiting, may also occur and can indicate distress or reaction to a substance, but they do not demonstrate the immediate and life-threatening nature of the situation as effectively as unresponsiveness and breathing issues do.