Which fruit juice is known to affect the metabolism of certain drugs?

Grapefruit juice is well-known for its ability to affect the metabolism of certain drugs due to the presence of compounds that inhibit the cytochrome P450 enzyme system, particularly CYP3A4. This enzyme is responsible for the metabolism of many medications, and when grapefruit juice is consumed, it can increase the concentration of these drugs in the bloodstream, leading to enhanced effects or potential toxicity. This interaction is significant because it can alter how medications behave in the body, affecting their efficacy and safety.

In contrast, other juices like orange, apple, and pineapple juice do not have the same pronounced effects on drug metabolism. While they may interact with certain medications to some extent, they do not exhibit the same level of impact as grapefruit juice, which has been extensively studied and documented for its interactions with a wide range of pharmaceuticals. Understanding this interaction is crucial for healthcare professionals to provide safe medication management and counseling for patients.